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Although vitamin C has an overall low toxicity risk in healthy individuals, consuming too much of it can cause some adverse gastrointestinal side effects, including cramps, nausea, and diarrhea (11, Additionally, since a high vitamin C intake increases the bodys absorption of non-heme iron, consuming too much vitamin C could cause problems for people with hemochromatosis, a condition in which the body retains too much iron ( Because of the potential side effects of excessive vitamin C, the IOM has established the following Tolerable Upper Intake Levels (UL) for the vitamin (11): summary To avoid gastrointestinal side effects, keep your vitamin C intake within the ULs established by the IOM

Conde-Martel et al., 2024), along with the usually disregarded yet significant role of the kidneys in glucose production (Stumvoll et al., 1999