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Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors

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First, no systematic profiling of key inflammatory cytokines has been performed, so the full regulatory map of the ferroptosisinflammationneovascularization axis remains sketchy: the exact spectrum of cytokines released upon iron overload and their divergent effects on ferroptosis versus neovascular signaling are still undefined