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Many studies report that sphingosine-1-phosphate is involved in various neurological and psychiatric disorders, including Alzheimers disease [63], depression, and anxiety [64]

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This review therefore aims to (1) summarize recent advances in metabolomics technologies relevant to diabetes, (2) elucidate key mechanisms of metabolic reprogramming, (3) highlight promising biomarkers and patient stratification strategies, and (4) discuss translational applications and future challenges

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