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Inhibition of the RNase activity of IRE1 by drugs reduces viral protein levels and viral titers produced by JEV-infected mouse neuroblastoma cells (Neuro2a), which suggests that the activation of the RIDD pathway may have a direct benefit on JEV replication (Bhattacharyya et al., 2014)

10.1016/j.biopha.2022.112752 79 KumarA.SundaramK.TengY.MuJ.SriwastvaM

Last reviewed: May 31, 2026 Last updated: May 31, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

There has also been a corresponding 22.6% reduction in the frequency of chromosomal defects in the bone marrow of the DSIP-exposed mice