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Most importantly, this protective phenotype appears to involve the following beneficial cellular adaptions: (i) enhanced metabolism of ethanol and acetaldehyde, (ii) suppression of lipogenic genes and induction of genes involved in fatty acid oxidation, and (iii) induction of the NRF2 antioxidant response and the AMPK metabolic signaling pathway

Chronic oxidative stress in T2DM impairs all major immune cell classes, creating a compounding vulnerability to infection, inflammation, and long-term complications

[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Ceriello A., Bortolotti N., Motz E., Crescentini A., Lizzio S., Russo A., Tonutti L., Taboga C