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Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by impaired insulin secretion, while type 2 diabetes mellitus (T2DM) is mainly caused by insufficient insulin secretion or insulin resistance

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The original FLOW (Evaluate Renal Function with Semaglutide Once Weekly) trial in 3533 patients with type 2 diabetes and CKD found subcutaneous semaglutide 1 mg once weekly reduced the risk of the primary kidney endpoint (at least a 50% decline of estimated glomerular filtration rate, kidney failure or kidney or cardiovascular death) by 24% and all-cause death by 20%

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