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Through this path of discovery, ammonium tetrathiomolybdate was used in WD, first by Walshe 80 (which he also reported at the Leeds Castle meeting) and then in a series of studies (and 1 randomized trial in which tetrathiomolybdate and trientine were compared in a double-blind design) by George Brewer and colleagues

The Protonix settlement demonstrates that even large generic manufacturers can face existential financial exposure from a failed at-risk strategy

Research into combination therapy remains limited, which is why individualized assessment and genetic insights into peptide-pathway responsiveness become essential