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Funding : This work was supported by National Key R&D Program of China (Grant ID: 2023YFC3402800), National Science Fund for Distinguished Young Scholars (Grant ID: 82225025), National Natural Science Foundation of China (Grant IDs: 32171296, 32271351, and 32471435), Guangdong Basic and Applied Basic Research Foundation for Distinguished Young Scholars (Grant ID: 2024B1515020057), and China Postdoctoral Science Foundation (Grant IDs: 2023TQ0134, GZC20230968, and 2024M751117)

Diarrhea Extreme weight loss Loss of appetite or eating more than usual Lack of energy Weakness Excessive sleepiness Refuses to exercise or play Lack of muscle mass Altered mental state Seizures Death Border Collie Giant Schnauzer Beagle Worried about the cost of treating your pet's symptoms

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Post-treatment, the media were collected