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The safety and efficacy of insulin therapy is closely related to glucose monitoring and insulin dose adjustments made by the individual with diabetes or, more recently, made automatically through control algorithms

A randomized controlled trial on the effect of metformin in CHD patients without diabetes showed that it (2000 mg/day, P.O for 12 months) not only decreased oxidative stress but also lowered left ventricular mass (LVM) and improved blood pressure [227]

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It was observed that cinnamonaldehyde had decreased the blood glucose through upregulating the expression of the GLUT4 gene