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193 Additionally, caspase-3 cleaves GSDME at its linker region, releasing an N-terminal fragment that activates pyroptosis through a mechanism similar to that of the GSDMD N-terminal domain

That made them a logical group of drugs to study in breast cancer populations, especially because preclinical work has suggested possible anticancer effects and because weight reduction itself may influence long-term outcomes

While higher doses are used in some clinical settings, a moderate, consistent daily dose (around 250mg to 500mg) is usually sufficient for maintaining healthy levels for the average adult

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