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Compared to the ICH group, the crocin-treated group significantly increased the activities of SOD and GSH-px ( 2+ concentration and the upregulation of GPX4, FTH1, and SLC7A11 genes demonstrated the inhibition of ferroptosis in neuron cells by crocin ( 6 Clinical translation discussion Compared with the previous review published by Zhou et al., we have summarized the mechanism of ferroptosis in stroke and summarized its natural products, rather than only focusing on ischemic stroke (Zhou et al., 2024b)