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GSH participates in thiol-disulfide exchange through a reversible reaction catalyzed by thiol-transferases as shown below, where Protein-SSG is a mixed disulfide and Protein-SH is reduced protein: The thiol-disulfide equilibrium is determined by the redox state of the cell, which is based on GSH and GSSG concentrations

Gastroenterol Hepatol 2014

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