Harlev A, Agarwal A, Gunes SO, Shetty A, du Plessis SS
Of these, 1,180 participants were excluded for the following reasons: initiation during hospitalization, initiation at another institution, having received only a single prescription for oral semaglutide, initiation at a dose other than 3 mg, treatment duration of less than 180 days, missing baseline laboratory data, changes in concomitant oral antidiabetic drugs, or prior use of injectable GLP-1 RAs
Blood Sugar Effects Both medications improve glucose metabolism: Liraglutide: HbA1c reduction of 0.5-1.0% at weight loss doses Originally developed for diabetes (Victoza) Modest glucose benefits at Saxenda doses Semaglutide: HbA1c reduction of 1.0-1.8% at diabetes doses Greater glucose improvement than liraglutide Significant benefit for prediabetes and diabetes For patients with diabetes or prediabetes, semaglutide provides greater metabolic benefit
The BBB, which is primarily composed of brain microvascular endothelial cells (BMVECs) in close association with astrocytic endfeet, serves as the principal gateway that stringently controls the entry of iron into the brain parenchyma ( 3+ dissociates from transferrin and is reduced to its ferrous form Fe 2+ prior to its transport into the cytosol via DMT1