semaglutide evoke trial Novo Nordisk said Monday that an older oral version of its diabetes treatment The EVOKE trials found that

2017 Jul 11;18(1):8

The tablets should be stored sealed, light-proof, in a cool and dry place, away from high temperature and humidity to prevent deterioration and loss of efficacy

Gastrointestinal Side Effects The most common adverse events were gastrointestinal in nature, as expected for this drug class: Nausea the most frequently reported GI side effect, typically most pronounced during dose escalation and diminishing over time Diarrhea reported at moderate frequency Constipation less common than nausea but clinically relevant for some participants Vomiting generally mild and often transient These GI effects are mechanistically linked to GLP-1 receptor activation (slowed gastric emptying, central appetite suppression) and are a recognized feature of all GLP-1-based therapies

Picomolar amyloid- peptides enhance spontaneous astrocyte calcium transients