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Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11

1998 Sep 1 [cited 2021 Aug 23];12(5):2738

Supporting cardiovascular health becomes even more important: Swap saturated fats (butter, processed meats) for heart-healthy fats (avocado, nuts, olive oil) Include oily fish such as salmon or sardines weekly for omega-3s Choose fibre-rich foods like oats, beans, and whole grains to help manage cholesterol 7

On average, participants returned to their original weight just 1.7 years after stopping the medication