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Great effort has been made to try and improve certain aspects of 3D models, such as application of microfluidic devices or organ-on-a-chip that provide microchambers and channels that improve nutrient distribution and growth factors [93]

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When a carboxylic acid (pH 4) is added to a solution containing an amine (R-NH 2 ), an acid-base reaction quickly occurs, resulting in formation of the ammonium salt R-NH 3 (+) with a pK a of about 9