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To ensure that experimental artifacts, such as ion suppression, did not lead to misinterpretation of metabolite levels, internal standards, namely, 2-( N -morpholino)ethanesulfonic acid, methionine sulfone, and d-camphor-10-sulfonic acid, were added to each sample (18, 57)

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Saqr AAL, Khafagy ES, Alalaiwe A, Aldawsari MF, Alshahrani SM, Anwer MK et al (2021) Synthesis of gold nanoparticles by using green machinery: Characterization and in vitro toxicity

Electronic Supplementary File (ESF) 1 and ESF 2 show the results of enrichment and annotation analyses performed on the DEPs (or selected DEPs), as given in Figure 1