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Homocysteine can be deviated from one carbon metabolism and, together with serine, enter in TSP to originate cysteine and propionyl-CoA under the action of CBS and CSE ( Methionine scarcity impairs cancer cells' proliferation ( SLC7A11 gene) ( As above mentioned, the methyl groups generated in the one-carbon metabolism, when released from methionine cycle, are crucial for DNA, RNA, and histones methylation for epigenetic modulation ( SLC7A5 ), the main transporter of methionine, is associated with the activity of methyltransferases in lung cancer cells (60)

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Sunanta P et al (2023) The nutritional value, bioactive availability and functional properties of Garlic and its related products during processing