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[33] broadened the scope to 26 studies ( n = 3,020), including both metabolic RCTs with secondary psychiatric outcomes and a small number of trials in clinical populations (e.g., substance use disorders)

Detailed Explanation of the Biological Pathways Semaglutide is a type of drug called a GLP-1 receptor agonist

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It has been shown previously that 14% weight loss due to a very-low-energy diet (VLED) resulted in counter-regulatory changes in appetite-regulating hormones, including a significant increase in fasting levels of ghrelin and significant reductions in the fasting levels of leptin, GLP-1, peptide YY (PYY), cholecystokinin (CCK) and amylin 48