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Key points commonly noted in trial reporting include: No clear signal of increased major adverse cardiovascular events (MACE) directly attributed to retatrutide so far Pancreatitis events are rare, with no definitive unique signal established specifically for retatrutide in the current evidence base Discontinuation rates rise at higher doses, consistent with dose-related GI intolerance The most frequent driver of discontinuation tends to be tolerability rather than a unique severe toxicity profile