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Additionally, future studies should be aimed at assessing the long-term health effects of tirzepatide including the risk of pancreatitis with direct comparison to lifestyle interventions, metformin, and placebo to help physicians make more informed recommendations for their patients with diabetes and/or obesity

The timing of the GLP-1 injection can influence sleep quality, with many women finding that morning or early afternoon administration is better tolerated than evening dosing

The combination with GLP-1 also appears to reduce the gastrointestinal side effects that sometimes limit GLP-1 only treatments, improving tolerance and long-term adherence

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