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It is important to distinguish between urinary changes related to GLP-1 therapy and those caused by other diabetes medications, particularly SGLT2 inhibitors (such as dapagliflozin, empagliflozin), which do directly increase urination as their primary mechanism of action

Cardiovascular biology of the incretin system

Wegovy is also the only weight loss injection approved to reduce the risk of major cardiovascular events , with trials showing a 20% reduction in events in overweight or obese adults

A small effect of the injection site shows up in absorption research, with bioavailability roughly 12 percent lower in the thigh compared with the abdomen