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Sources Wilding JPH et al

Four critical genetic variantsincluding GIPR rs1800437, GLP1R rs6923761, FTO rs9939609, and MC4R rs17782313determine baseline sensitivity to semaglutide and tirzepatide

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GLP-1s offer significant promise to millions of Americans living with obesity, diabetes and/or cardiovascular disease, but their unprecedented demand and high price tags are creating challenging downstream impacts, including fluctuating supply, inconsistent clinical support, and runaway cost trajectory, said an Evernorth statement