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There are not many studies done using intravenous vitamins, but I have seen up to 10 grams of vitamin C per day given without any problems

This receptor-mediated action adds a second layer of immune modulation on top of the direct NF-kB suppression

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Indeed, we observed increased KEAP1 and decreased NRF2 in both macrophages and RANKL-induced osteoclasts, as well as in ankle joints of CIA mouse models, indicating an unbalanced redox environment (Fig