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Antioxidants and redox regulation of cellular signaling: Introduction

Accessed Jan 19, 2026 at Khera R, Murad MH, Chandar AK, et al

The role of copper in this regard is argued to be protective, with copper being released into the synaptic cleft at concentrations of up to 100 M upon depolarization, inhibiting the activity of postsynaptic NMDA, AMPA, and GABA receptors upon binding, thus preventing overstimulation in a negative feedback system (DAmbrosi and Rossi, 2015)