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The trial also featured a "novel, patient-centric approach to clinical trial design." Placebo participants who regained 50% or more of their weight were eligible for rescue therapy with orforglipron

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While the mechanisms underlying APAP-mediated lysosomal instability or permeabilization are not fully understood, the iron chelator desferal prevented mitochondrial depolarization and hepatocellular death after APAP exposure (Kon et al., 2010)

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