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Broadstock, M., Ballard, C

Although the effect of mB12/LDFA and BH4 on methylation and glutathione metabolism have been examined in the open-label studies, these changes have not been compared to controls who received a placebo in order to account for the natural variation in the changes in these pathways

doi: 10.1111/j.1462-2920.2007.01369.x [DOI] [PubMed] [Google Scholar] 233

Continuous use advantages include maintaining peak benefits without decline periods, avoiding the uncertainty of whether improvements will persist after breaks, simplifying routine through consistency, and potentially maximizing cumulative collagen synthesis through sustained stimulation over months to years