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flavonoids including quercetin and epigallocatechin gallate modulate phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling, restricting proliferation and metabolic adaptation (Melim et al., 2022)
PLoS ONE 2 , e880 (2007)
(C) F = 9.39, P = 0.0001 Previous reports have suggested that at least some of the clinical effects of acetaminophen could be due to its metabolism to AM404 or the deacetylated intermediate, p-aminophenol [47]
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