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The study also assessed secondary outcomes related to immune function in a subset of participants

The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair

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Although GCs are important in maintaining lipid homeostasis, an excess of GCs can lead to an increase in circulating free fatty acids and cause lipid accumulation in skeletal muscle and liver also associated with insulin resistance [80]