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The concerted efforts of synthetic chemists over the years have led to a common understating that organo-selenium compounds depending on their chemical structure can mimic GPx-like activity [71,72,73]

We also acknowledge that MAD itself may be proximal to other risk factors, especially diet, since the diet can greatly affect the oral and gut microbiomes, metabolic state and infection susceptibility (Santonocito et al., 2022

Th17-derived cytokines also promote intracellular iron accumulation in structural lung cells, further accelerating ferroptotic damage

Edaravone has also only been shown to be effective in a small subset of patients with ALS