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The contribution of metabolic mediators to IR Adipokines dysregulation and IR Adipose tissue can secrete various bioactive circulating mediators referred as adipokines, like adiponectin, leptin, chemerin, resistin, visfatin and vaspin, in addition to cytokines and chemokines such as tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), IL-1, and monocyte chemoattractant protein-1

The researchers wondered whether the genetic glitch also affects GLP-1, a gut hormone that plays an important role in blood sugar control after a meal by stimulating insulin release, slowing stomach emptying and reducing appetite

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