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The SUSTAIN-6 cardiovascular outcomes trial established that semaglutide also reduces the risk of major adverse cardiovascular events (MACE) by 26% relative to placebo in high-risk patients a finding that fundamentally changed the treatment landscape for metabolic disease
In fact, only a modest improvement in insulin resistance was consistently detected in PWA mice following treatment with metformin, as reflected by a moderately reduced HOMA-IR index
[ [PMID: 23966981] [70] Massie, A
Most healthcare providers recommend staying on these medications for one to two years to maintain weight loss
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