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Survival of retinal ganglion cells is promoted by BDNF and is thought that it can be used as a therapeutic agent in glaucoma neuropathy due to its neuroprotective properties [121]

Additionally, the expression of mRNA and protein for both 25-hydroxylases (CYP2R1 and CYP27A1), 1--hydroxylase (CYP27B1), and VDR were downregulated, but that of 24-hydroxylase (CYP24A1) was significantly upregulated in the liver of HFD-fed mice compared to those in controls (Fig

4b, d, e)

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