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The administration of flavonoids to diabetic animals boosts the antioxidant potential of -cells by increasing both enzymatic and non-enzymatic antioxidants, consequently limiting ROS generation and lipid peroxidation in -cells and protecting them against autophagy, apoptosis, or necroptosis (73, 74)

It ebbed and reappeared again around week four, which makes sense from what we know of tirzepatides half-life (of approximately five days), as it takes roughly four to five weeks of regular dosing to reach a steady state in the body where drug levels stabilise at a consistently higher baseline than in the early weeks