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Deficiency has also been linked with a higher likelihood of pre-eclampsia, gestational diabetes and excess weight gain during pregnancy

Injection site reactions including temporary redness, minor swelling, or brief discomfort occur in some users but typically resolve within hours

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The direct, quantified, longitudinal human measurements that would settle it are largely absent from the published cagrilintide monotherapy literature, and there is a credible mechanistic reason the tendency of long-acting gut-hormone agonists toward gastric-emptying tachyphylaxis, plus obesity-associated amylin-receptor down-regulation to suspect the gastric arm may attenuate even as central satiety persists