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Therefore, intact proteins confer performance benefits by engaging the same molecular targets as individual amino acids, including the mTORC1S6K14E-BP1 axis for stimulating muscle protein synthesis and the insulinIGF-1PI3KAkt cascade for promoting anabolism and glycogen storage, but they do so through a more sustained release profile that prolongs pathway activation (30)

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A narrative review concluded that the practice is controversial because there are no standardized dosing protocols and nearly onethird of patients report adverse effects, ranging from mild gastrointestinal symptoms to liver dysfunction and lifethreatening allergic reactions

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