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Pembrolizumab and nivolumab which have also been in a category of immune checkpoint inhibitors are approved by FDA as a first line therapy in patients having cisplatin insensitive recurrent or metastatic HNSCC [19,20,21]

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As the field advances, it is anticipated that new discoveries will enhance our understanding, paving the way for more effective and targeted use of GPS in clinical settings

Nofreezing reconstituted peptides causes ice crystal formation that physically disrupts peptide structure and reduces bioactivity by 4060%