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A subgroup analysis of the SELECT trial showed that semaglutide 2.4 mg/week was effective in lowering the risk of MACEs by 21% and 36% in patients with an intermediate and high likelihood of advanced liver fibrosis, as identified by a baseline FIB4 index of 1.3 and 2.67, respectively

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It carries a boxed warning regarding the risk of thyroid C-cell tumors observed in rodent studies and should not be used by individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, during pregnancy, or where otherwise contraindicated

Because different studies use different preparation protocols, comparing between the results becomes more difficult, and the reproducibility of findings is often limited