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Rarely, metformin can contribute to lactic acidosis, a serious condition more likely in settings such as severe kidney impairment, severe liver disease, heavy alcohol use, or acute illness with dehydration

December 2025: An oral form of Wegovy was approved, making it the first oral semaglutide approved for weight loss on the market

Based on these findings, the authors postulate that green tea might compromise tear quality and advocate further investigation into this phenomenon (Masmali et al., 2019)

What Current Evidence and Clinical Trials Tell Us The key published evidence is a 2023 Phase 2 RCT (Jastreboff et al.) showing substantial weight loss and predominantly mild-to-moderate GI side effects