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In H9c2 cardiomyoblasts, GLP-1RAs protect against cell apoptosis and inhibit the expression of tumor protein P53 (p53)

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At 24 weeks, the mean change body weight was 7.2% with 1 mg, 11.8% with 4 mg (starting with 2 mg), 13.9% with 4 mg (starting with 4 mg), 16.7% with 8 mg (starting with 2 mg), 17.9% with 8 mg (starting with 4 mg), and 17.5% with 12 mg (starting with 2 mg), compared to 1.6% in the placebo group [38]

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