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In vitro, we have demonstrated that GADD45A, as a reader of R-loops, can recognize the R-loop near the upstream of the KCNQ5 promoter (exon 2 of KCNQ5-DT) formed by ssDNA and lncRNA ( KCNQ5-DT ), mediating the epigenetic regulation of KCNQ5 by guiding TET1

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