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The molecule was first isolated by Pickart in 1973 as the active component of human albumin fraction responsible for inducing older liver tissue to synthesize proteins characteristic of younger tissue an observation that led to subsequent decades of research into GHK-Cus effects on wound healing, skin regeneration, gene expression, and cellular senescence

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Additional information Peer review information Nature thanks Michael Murphy, Tracey Rouault and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Ranadheera, S., & Ajlouni, S