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A similar pattern was observed in the SURMOUNT-4 trial for tirzepatide: after participants lost an average of 20.9% of their body weight during a 36-week lead-in phase, those who stopped treatment regained about 14%, while those who continued taking tirzepatide lost an additional 5.5% over the next year

Fecal microbiota in pediatric inflammatory bowel disease and its relation to inflammation