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Active secretion begins at the blastocyst stage, enabling hCG detection in the maternal circulation approximately 10 days after fertilisation, with the highest values reached between the 10th and 11th week of pregnancy before declining through the remainder of the first trimester

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That is what makes it different from most topical treatments, which address the surface of a specific area, or from peptides like BPC-157, which address a specific type of tissue damage