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Clinical trials show mood-related adverse events occur in a small percentage of users, typically during dose escalation

Other popular GLP-1 drugs include: Originally developed to reduce blood glucose in type 2 diabetes only, research published in the New England Journal of Medicine in 2021 documenting the powerful weight loss effects of the active ingredient semaglutide began the movement to prescribe GLP-1 receptor agonists as an off-label weight-loss drug

Taheri S, Saffaei A, Amani B, Akbarzadeh A, Peiravian F, Yousefi N 2019 Efficacy and Safety of Dulaglutide Compared to Liraglutide: A Systematic Review and Meta-analysis in Patients with Type 2 Diabetes Mellitus

Nearly half of everyone on high-dose semaglutide experienced nausea at some point during the trial