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Mechanisms of Insulin Resistance Effected by Ceramides Numerous lines of evidence have shown that various inducers of cellular stress such as inflammatory activation, excess saturated fatty acid intake, and chemotherapeutics, result in increased rates of ceramide synthesis

IGF-1 itself is a hormone similar in structure to insulin and plays a critical role in muscle growth, cell repair, and tissue regeneration

If the FDA will require outcomes trials for future approvals in obesity, this will add considerable time and cost to drug development

Bands were quantified using Image Lab Version 2.0.1 (Bio-Rad, Hercules, CA)