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Parameters to monitor Serum electrolytes (especially creatinine and potassium) Symptoms of angioedema BP Symptoms of hypotension CBC (especially with captopril and enalapril) for neutropenia, which is more common in patients with preexisting renal impairment Cough Urinary proteins Direct Renin Inhibitors See Table 12-16 for a list of direct renin inhibitors, their usual dosage range, and adverse effects associated with these medications

Secondary outcomes Five included studies comprising 3605 patients reported change in MCV, four studies comprising 140 patients reported change in homocysteine levels, four studies comprising 3588 patients reported change in platelets count, and only three studies with 3430 patients reported change in WBC count

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