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As a GLP-1 receptor agonist, semaglutide mimics the actions of endogenous GLP-1 but with one critical engineering advantage: while native GLP-1 has a biological half-life of only a few minutes before being cleaved by the enzyme DPP-4, semaglutide achieves a half-life of approximately seven days through structural modifications that include an Aib amino acid substitution at position 8 (blocking DPP-4 recognition) and a C18 fatty acid chain attached via a linker, which enables reversible binding to albumin in the bloodstream

Packaged food companies are also responding to the growth of GLP-1s with marketing to make their products appear healthier

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists (updated meta-analysis) Sattar N et al

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