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Follow up PET examinations were performed after 17 (GCGR) and 20 (GLP-1R) days of treatment with SAR425899, to assess the occupancy at each receptor

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The accumulation of toxic substances leads to oxidative damage to cells and a decrease in Na + -K + -ATPase activity, which results in the activation of NMDA receptors, neuronal depolarization, and clinical symptoms such as seizures

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