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For experiments in 384-well plates, wells were aspirated, rinsed with PBS and incubated with a fixative and staining solution containing 3.7% formaldehyde (Fisher Scientific, F75P-1GAL) and 5 g ml 1 Hoechst 33342, trihydrochloride, trihydrate (Invitrogen, H1399)

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These findings demonstrate both a novel cancer treatment strategy and the ecological risk of heavy metal mixtures (181, 182)

Platelet intrinsic apoptosis relies on the mitochondrial apoptosome-mediated caspase-9/caspase-3-dependent mechanism, is tightly regulated by Bcl-XL, Bak, and Bax, and lacks the Fas receptor present on erythrocytes [499]